īirth cohort data from the Avon Longitudinal Study of Parents and Children (ALSPAC) have been used to describe childhood sleep patterns from 6 months to 11 years of age and to estimate the prevalence of ‘chronic disabling fatigue’ (CDF, a proxy for clinically diagnosed CFS/ME) at ages 13, 16 and 18 years. These include sleep abnormalities and CFS/ME sharing a common cause (physiological, neurological, etc.), CFS/ME precipitating or perpetuating sleep dysfunction or vice versa, or abnormal sleep in patients with CFS/ME being a symptom of common CFS/ME-related comorbidities such as low mood and chronic pain. Whilst abnormal sleep is part of the clinical picture of CFS/ME, and a major feature of the lived experience of adult and paediatric patients, hypothetical causal pathways that associate sleep dysfunction with CFS/ME have not been substantiated. Both criteria specify disturbed or unrefreshing sleep as one of the typical symptoms of CFS/ME, and this symptom has been recorded in 95–97% of adult and adolescent (age 12–18 years) patients, and in 85% of paediatric patients under 12 years of age. The widely used CDC/Fukuda diagnostic criteria require six months’ duration of fatigue and the presence of four of eight typical symptoms.
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The UK National Institute for Health and Care Excellence (NICE) guidelines state that diagnosis of CFS/ME should be made after three months of persistent or recurrent fatigue that is not the result of ongoing exertion, not substantially alleviated by rest, has resulted in a substantial reduction in activities, has no other known cause and is accompanied by one or more of ten typical symptoms. Chronic fatigue syndrome (CFS, also known as Myalgic encephalomyelitis ) in children and young people is a debilitating disease with an adverse effect on the lives of children and their families.